Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen
Identifieur interne : 001A28 ( Main/Exploration ); précédent : 001A27; suivant : 001A29Virological and serological analysis of a recent Middle East respiratory syndrome coronavirus infection case on a triple combination antiviral regimen
Auteurs : Nikolaos Spanakis [Grèce] ; Sotirios Tsiodras [Grèce] ; Bart L. Haagmans [Pays-Bas] ; V. Stalin Raj [Pays-Bas] ; Kostantinos Pontikis [Grèce] ; Antonia Koutsoukou [Grèce] ; Nikolaos G. Koulouris [Grèce] ; Albert D. M. E. Osterhaus [Pays-Bas] ; Marion P. G. Koopmans [Pays-Bas] ; Athanassios Tsakris [Grèce]Source :
- International Journal of Antimicrobial Agents [ 0924-8579 ] ; 2014.
Descripteurs français
- KwdFr :
- Antiviraux (usage thérapeutique), Association de médicaments, Association médicamenteuse, Coronavirus du syndrome respiratoire du Moyen-Orient (), Coronavirus du syndrome respiratoire du Moyen-Orient (génétique), Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie), Excrétion virale, Grèce, Humains, Infections de l'appareil respiratoire (traitement médicamenteux), Infections de l'appareil respiratoire (virologie), Infections à coronavirus (traitement médicamenteux), Infections à coronavirus (virologie), Lopinavir, Mâle, Phylogénie, Ribavirine (usage thérapeutique), Ritonavir, Virémie.
- MESH :
- génétique : Coronavirus du syndrome respiratoire du Moyen-Orient.
- immunologie : Coronavirus du syndrome respiratoire du Moyen-Orient.
- traitement médicamenteux : Infections de l'appareil respiratoire, Infections à coronavirus.
- usage thérapeutique : Antiviraux, Ribavirine.
- virologie : Infections de l'appareil respiratoire, Infections à coronavirus.
- Association de médicaments, Association médicamenteuse, Coronavirus du syndrome respiratoire du Moyen-Orient, Excrétion virale, Grèce, Humains, Lopinavir, Mâle, Phylogénie, Ritonavir, Virémie.
English descriptors
- KwdEn :
- Antiviral Agents (therapeutic use), Coronavirus Infections (drug therapy), Coronavirus Infections (virology), Drug Combinations, Drug Therapy, Combination, Greece, Humans, Lopinavir, Male, Middle East Respiratory Syndrome Coronavirus (drug effects), Middle East Respiratory Syndrome Coronavirus (genetics), Middle East Respiratory Syndrome Coronavirus (immunology), Phylogeny, Respiratory Tract Infections (drug therapy), Respiratory Tract Infections (virology), Ribavirin (therapeutic use), Ritonavir, Viremia, Virus Shedding.
- MESH :
- chemical , therapeutic use : Antiviral Agents, Ribavirin.
- drug effects : Middle East Respiratory Syndrome Coronavirus.
- drug therapy : Coronavirus Infections, Respiratory Tract Infections.
- genetics : Middle East Respiratory Syndrome Coronavirus.
- immunology : Middle East Respiratory Syndrome Coronavirus.
- virology : Coronavirus Infections, Respiratory Tract Infections.
- chemical : Drug Combinations, Drug Therapy, Combination, Greece, Humans, Lopinavir, Male, Phylogeny, Ritonavir, Viremia, Virus Shedding.
Abstract
Serological, molecular and phylogenetic analysis of a recently imported case of MERS coronavirus (MERS-CoV) in Greece. MERS-CoV remained detectable in the respiratory tract secretions of the patient until the fourth week of illness, whereas viraemia was last detected two days after the institution of the triple combination therapy. The non-detectable viral RNA in serum by day 3 after the initiation of the antiviral treatment could be explained either by viral clearance in an otherwise immunocompetent person or by effectiveness of the instituted antiviral regimen.
Url:
DOI: 10.1016/j.ijantimicag.2014.07.026
PubMed: 25288266
PubMed Central: 7127532
Affiliations:
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Stalin Raj</name><affiliation wicri:level="3"><nlm:aff id="aff0020">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Pontikis, Kostantinos" sort="Pontikis, Kostantinos" uniqKey="Pontikis K" first="Kostantinos" last="Pontikis">Kostantinos Pontikis</name><affiliation wicri:level="3"><nlm:aff id="aff0025">First Department of Respiratory Medicine, University of Athens Medical School and ‘Sotiria’ Chest Diseases Hospital, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>First Department of Respiratory Medicine, University of Athens Medical School and ‘Sotiria’ Chest Diseases Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Koutsoukou, Antonia" sort="Koutsoukou, Antonia" uniqKey="Koutsoukou A" first="Antonia" last="Koutsoukou">Antonia Koutsoukou</name><affiliation wicri:level="3"><nlm:aff id="aff0025">First Department of Respiratory Medicine, University of Athens Medical School and ‘Sotiria’ Chest Diseases Hospital, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>First Department of Respiratory Medicine, University of Athens Medical School and ‘Sotiria’ Chest Diseases Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Koulouris, Nikolaos G" sort="Koulouris, Nikolaos G" uniqKey="Koulouris N" first="Nikolaos G." last="Koulouris">Nikolaos G. Koulouris</name><affiliation wicri:level="3"><nlm:aff id="aff0025">First Department of Respiratory Medicine, University of Athens Medical School and ‘Sotiria’ Chest Diseases Hospital, Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>First Department of Respiratory Medicine, University of Athens Medical School and ‘Sotiria’ Chest Diseases Hospital, Athens</wicri:regionArea><placeName><settlement type="city">Athènes</settlement><region nuts="2" type="region">Attique (région)</region></placeName></affiliation></author><author><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. 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Koopmans</name><affiliation wicri:level="3"><nlm:aff id="aff0020">Department of Viroscience, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Viroscience, Erasmus Medical Center, Rotterdam</wicri:regionArea><placeName><settlement type="city">Rotterdam</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Tsakris, Athanassios" sort="Tsakris, Athanassios" uniqKey="Tsakris A" first="Athanassios" last="Tsakris">Athanassios Tsakris</name><affiliation wicri:level="1"><nlm:aff id="aff0005">Department of Microbiology, University of Athens, Medical School, 75 Mikras Asias Street, 115 27 Athens, Greece</nlm:aff><country xml:lang="fr">Grèce</country><wicri:regionArea>Department of Microbiology, University of Athens, Medical School, 75 Mikras Asias Street, 115 27 Athens</wicri:regionArea><wicri:noRegion>115 27 Athens</wicri:noRegion></affiliation></author></analytic><series><title level="j">International Journal of Antimicrobial Agents</title><idno type="ISSN">0924-8579</idno><idno type="eISSN">1872-7913</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiviral Agents (therapeutic use)</term><term>Coronavirus Infections (drug therapy)</term><term>Coronavirus Infections (virology)</term><term>Drug Combinations</term><term>Drug Therapy, Combination</term><term>Greece</term><term>Humans</term><term>Lopinavir</term><term>Male</term><term>Middle East Respiratory Syndrome Coronavirus (drug effects)</term><term>Middle East Respiratory Syndrome Coronavirus (genetics)</term><term>Middle East Respiratory Syndrome Coronavirus (immunology)</term><term>Phylogeny</term><term>Respiratory Tract Infections (drug therapy)</term><term>Respiratory Tract Infections (virology)</term><term>Ribavirin (therapeutic use)</term><term>Ritonavir</term><term>Viremia</term><term>Virus Shedding</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Antiviraux (usage thérapeutique)</term><term>Association de médicaments</term><term>Association médicamenteuse</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient ()</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (génétique)</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient (immunologie)</term><term>Excrétion virale</term><term>Grèce</term><term>Humains</term><term>Infections de l'appareil respiratoire (traitement médicamenteux)</term><term>Infections de l'appareil respiratoire (virologie)</term><term>Infections à coronavirus (traitement médicamenteux)</term><term>Infections à coronavirus (virologie)</term><term>Lopinavir</term><term>Mâle</term><term>Phylogénie</term><term>Ribavirine (usage thérapeutique)</term><term>Ritonavir</term><term>Virémie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term><term>Ribavirin</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Coronavirus Infections</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Middle East Respiratory Syndrome Coronavirus</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Infections de l'appareil respiratoire</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term><term>Ribavirine</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Infections de l'appareil respiratoire</term><term>Infections à coronavirus</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Coronavirus Infections</term><term>Respiratory Tract Infections</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Drug Combinations</term><term>Drug Therapy, Combination</term><term>Greece</term><term>Humans</term><term>Lopinavir</term><term>Male</term><term>Phylogeny</term><term>Ritonavir</term><term>Viremia</term><term>Virus Shedding</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Association de médicaments</term><term>Association médicamenteuse</term><term>Coronavirus du syndrome respiratoire du Moyen-Orient</term><term>Excrétion virale</term><term>Grèce</term><term>Humains</term><term>Lopinavir</term><term>Mâle</term><term>Phylogénie</term><term>Ritonavir</term><term>Virémie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Highlights</title><p><list list-type="simple" id="lis0005"><list-item id="lsti0005"><label>•</label><p id="par0005">Serological, molecular and phylogenetic analysis of a recently imported case of MERS coronavirus (MERS-CoV) in Greece.</p></list-item><list-item id="lsti0010"><label>•</label><p id="par0010">MERS-CoV remained detectable in the respiratory tract secretions of the patient until the fourth week of illness, whereas viraemia was last detected two days after the institution of the triple combination therapy.</p></list-item><list-item id="lsti0015"><label>•</label><p id="par0015">The non-detectable viral RNA in serum by day 3 after the initiation of the antiviral treatment could be explained either by viral clearance in an otherwise immunocompetent person or by effectiveness of the instituted antiviral regimen.</p></list-item></list></p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="European Centre For Disease Prevention And Control" uniqKey="European Centre For Disease Prevention And Control">European Centre for Disease Prevention and Control</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Al Tawfiq, J A" uniqKey="Al Tawfiq J">J.A. 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Abutarbush</name></author></analytic></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Grèce</li><li>Pays-Bas</li></country><region><li>Attique (région)</li><li>Hollande-Méridionale</li></region><settlement><li>Athènes</li><li>Rotterdam</li></settlement></list><tree><country name="Grèce"><noRegion><name sortKey="Spanakis, Nikolaos" sort="Spanakis, Nikolaos" uniqKey="Spanakis N" first="Nikolaos" last="Spanakis">Nikolaos Spanakis</name></noRegion><name sortKey="Koulouris, Nikolaos G" sort="Koulouris, Nikolaos G" uniqKey="Koulouris N" first="Nikolaos G." last="Koulouris">Nikolaos G. Koulouris</name><name sortKey="Koutsoukou, Antonia" sort="Koutsoukou, Antonia" uniqKey="Koutsoukou A" first="Antonia" last="Koutsoukou">Antonia Koutsoukou</name><name sortKey="Pontikis, Kostantinos" sort="Pontikis, Kostantinos" uniqKey="Pontikis K" first="Kostantinos" last="Pontikis">Kostantinos Pontikis</name><name sortKey="Tsakris, Athanassios" sort="Tsakris, Athanassios" uniqKey="Tsakris A" first="Athanassios" last="Tsakris">Athanassios Tsakris</name><name sortKey="Tsiodras, Sotirios" sort="Tsiodras, Sotirios" uniqKey="Tsiodras S" first="Sotirios" last="Tsiodras">Sotirios Tsiodras</name><name sortKey="Tsiodras, Sotirios" sort="Tsiodras, Sotirios" uniqKey="Tsiodras S" first="Sotirios" last="Tsiodras">Sotirios Tsiodras</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Haagmans, Bart L" sort="Haagmans, Bart L" uniqKey="Haagmans B" first="Bart L." last="Haagmans">Bart L. Haagmans</name></region><name sortKey="Koopmans, Marion P G" sort="Koopmans, Marion P G" uniqKey="Koopmans M" first="Marion P. G." last="Koopmans">Marion P. G. Koopmans</name><name sortKey="Osterhaus, Albert D M E" sort="Osterhaus, Albert D M E" uniqKey="Osterhaus A" first="Albert D. M. E." last="Osterhaus">Albert D. M. E. Osterhaus</name><name sortKey="Raj, V Stalin" sort="Raj, V Stalin" uniqKey="Raj V" first="V. Stalin" last="Raj">V. Stalin Raj</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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